Motif ID: TAL1_TCF{3,4,12}.p2

Z-value: 1.162


Transcription factors associated with TAL1_TCF{3,4,12}.p2:

Gene SymbolEntrez IDGene Name
TAL1 6886 T-cell acute lymphocytic leukemia 1
TCF12 6938 transcription factor 12
TCF3 6929 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
TCF4 6925 transcription factor 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
TCF4chr18_-_53177999-0.893.6e-09Click!
TCF12chr15_+_57210972-0.862.9e-08Click!
TAL1chr1_-_47695442-0.376.6e-02Click!
TCF3chr19_-_16523270.377.0e-02Click!


Activity profile for motif TAL1_TCF{3,4,12}.p2.

activity profile for motif TAL1_TCF{3,4,12}.p2


Sorted Z-values histogram for motif TAL1_TCF{3,4,12}.p2

Sorted Z-values for motif TAL1_TCF{3,4,12}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TAL1_TCF{3,4,12}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_150738232 9.377 CTSS
cathepsin S
chr2_+_152214105 8.791 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr1_-_150738255 7.273 CTSS
cathepsin S
chr1_-_150738292 5.481 NM_001199739
NM_004079
CTSS

cathepsin S

chr9_+_72658496 4.906 NM_153267
MAMDC2
MAM domain containing 2
chr2_+_167744996 3.085 NM_001079810
NM_001199143
NM_152381
XIRP2


xin actin-binding repeat containing 2


chr2_-_152146373 2.665 NM_004688
NMI
N-myc (and STAT) interactor
chr8_+_54764367 2.630 NM_170587
RGS20
regulator of G-protein signaling 20
chrX_-_154563735 2.620 NM_001289
CLIC2
chloride intracellular channel 2
chr17_+_6659155 2.396 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr4_-_76957139 2.375 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr13_+_97874704 2.242 MBNL2
muscleblind-like 2 (Drosophila)
chr18_+_21572736 1.989 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr9_+_72658735 1.971 MAMDC2
MAM domain containing 2
chr17_-_49124128 1.916 NM_001251971
SPAG9
sperm associated antigen 9
chr16_-_69385656 1.810 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr14_-_61748510 1.654 NM_001017970
TMEM30B
transmembrane protein 30B
chr10_-_73848530 1.549 NM_001244950
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr22_-_36556781 1.470 NM_145640
APOL3
apolipoprotein L, 3
chr16_+_2587951 1.345 NM_002613
NM_031268
PDPK1

3-phosphoinositide dependent protein kinase-1

chr13_-_27334777 1.338 NM_005288
GPR12
G protein-coupled receptor 12
chr13_+_97874540 1.254 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr9_-_85946875 1.188 NM_001244961
FRMD3
FERM domain containing 3
chr10_-_73848766 1.165 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr5_-_142783975 1.145 NM_001018076
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr22_+_36649172 1.118 APOL1
apolipoprotein L, 1
chr1_-_220219853 1.060 EPRS
glutamyl-prolyl-tRNA synthetase
chr6_-_128841432 1.058 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr19_-_4338750 1.051 NM_001013841
NM_017720
STAP2

signal transducing adaptor family member 2

chr10_-_14050453 1.023 FRMD4A
FERM domain containing 4A
chrY_-_21239250 0.995 TTTY14
testis-specific transcript, Y-linked 14 (non-protein coding)
chr5_-_131879172 0.953 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr7_-_41742666 0.912 NM_002192
INHBA
inhibin, beta A
chr6_+_126240369 0.883 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr1_+_50569581 0.878 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_+_75874512 0.848 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr3_-_195310985 0.848 NM_001647
APOD
apolipoprotein D
chr5_-_58571916 0.845 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_-_55277653 0.842 RTN4
reticulon 4
chr3_-_195310770 0.833 APOD
apolipoprotein D
chr22_+_36649116 0.832 NM_001136540
NM_001136541
NM_003661
NM_145343
APOL1



apolipoprotein L, 1



chr6_-_163148798 0.811 PARK2
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
chr16_+_2587989 0.802 PDPK1
3-phosphoinositide dependent protein kinase-1
chr2_+_231281470 0.799 NM_001206704
SP100
SP100 nuclear antigen
chr4_-_20985547 0.750 KCNIP4
Kv channel interacting protein 4
chr3_-_190167597 0.741 NM_207316
TMEM207
transmembrane protein 207
chrX_-_110513750 0.737 NM_014289
CAPN6
calpain 6
chr9_+_35673852 0.726 NM_001216
CA9
carbonic anhydrase IX
chr1_+_50571963 0.723 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_+_167718485 0.718 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr12_-_62586547 0.716 NM_178539
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr2_-_55277672 0.708 RTN4
reticulon 4
chr2_-_55277620 0.700 RTN4
reticulon 4
chr17_-_1090562 0.698 NM_001159746
ABR
active BCR-related gene
chr16_+_2588000 0.685 PDPK1
3-phosphoinositide dependent protein kinase-1
chr21_-_27423423 0.676


chr13_+_97928196 0.664 MBNL2
muscleblind-like 2 (Drosophila)
chr7_+_18548899 0.660 NM_001204147
NM_001204148
HDAC9

histone deacetylase 9

chr5_+_173472737 0.660 HMP19
HMP19 protein
chr1_-_220219874 0.650 NM_004446
EPRS
glutamyl-prolyl-tRNA synthetase
chr1_-_220219833 0.635 EPRS
glutamyl-prolyl-tRNA synthetase
chr11_+_67222817 0.634 NM_145200
CABP4
calcium binding protein 4
chr3_+_133494275 0.628 TF
transferrin
chr2_-_55277698 0.627 NM_020532
NM_153828
NM_207520
RTN4


reticulon 4


chr16_-_29910340 0.622 NM_001114099
NM_001114100
NM_001243332
NM_001243333
NM_012410
NM_201575
SEZ6L2





seizure related 6 homolog (mouse)-like 2





chr11_-_62689011 0.614 NM_000738
CHRM1
cholinergic receptor, muscarinic 1
chr2_-_55277459 0.606 RTN4
reticulon 4
chr2_-_55277592 0.602 RTN4
reticulon 4
chr12_+_12764755 0.591 NM_001310
CREBL2
cAMP responsive element binding protein-like 2
chrX_+_38211735 0.588 NM_000531
OTC
ornithine carbamoyltransferase
chrX_+_47082416 0.578 NM_001170460
CDK16
cyclin-dependent kinase 16
chr6_-_11382501 0.561 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr4_+_55095263 0.558 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr6_-_163148800 0.541 NM_004562
NM_013987
NM_013988
PARK2


parkinson protein 2, E3 ubiquitin protein ligase (parkin)


chr1_-_207205996 0.537 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr13_+_108922560 0.536 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr5_+_173472692 0.531 NM_015980
HMP19
HMP19 protein
chr9_-_14722669 0.528 NM_005454
CER1
cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)
chr2_+_187464931 0.522 NM_001144999
ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr4_-_111563278 0.510 NM_001204397
NM_001204398
NM_001204399
NM_153426
NM_153427
PITX2




paired-like homeodomain 2




chr1_-_23521221 0.507 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chrX_-_48056198 0.499 NM_021015
NM_175723
SSX5

synovial sarcoma, X breakpoint 5

chr11_+_46694514 0.492 ATG13
ATG13 autophagy related 13 homolog (S. cerevisiae)
chr11_-_62688732 0.490 CHRM1
cholinergic receptor, muscarinic 1
chr6_-_66417069 0.452 NM_001142800
NM_001142801
EYS

eyes shut homolog (Drosophila)

chr7_+_155437143 0.451 RBM33
RNA binding motif protein 33
chrX_+_128913881 0.444 NM_018990
SASH3
SAM and SH3 domain containing 3
chr3_-_167191808 0.442 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr1_+_24069961 0.441 TCEB3
transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
chr20_+_46130600 0.435 NM_001174087
NM_001174088
NM_006534
NM_181659
NCOA3



nuclear receptor coactivator 3



chr3_-_10332408 0.433 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chrX_+_16804531 0.433 NM_001168683
NM_018360
TXLNG

taxilin gamma

chr11_+_65407591 0.430 NM_153253
SIPA1
signal-induced proliferation-associated 1
chr11_-_58611979 0.419 NM_145016
GLYATL2
glycine-N-acyltransferase-like 2
chr11_-_63684315 0.416 NM_173587
RCOR2
REST corepressor 2
chr7_-_155437056 0.412


chr10_-_121296044 0.405 NM_002925
RGS10
regulator of G-protein signaling 10
chr8_-_20040612 0.402 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr20_+_60174816 0.391 NM_001252339
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr12_+_12764844 0.390 CREBL2
cAMP responsive element binding protein-like 2
chr1_-_160681552 0.389 NM_001778
CD48
CD48 molecule
chr3_-_11623829 0.386 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr13_+_108922474 0.383 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr19_+_15904760 0.366 NM_001004466
OR10H5
olfactory receptor, family 10, subfamily H, member 5
chr1_+_86934525 0.365 NM_001285
CLCA1
chloride channel accessory 1
chr2_-_89513056 0.357 IGKC
immunoglobulin kappa constant
chr7_-_44105162 0.356 NM_000290
PGAM2
phosphoglycerate mutase 2 (muscle)
chrX_+_103031753 0.355 NM_000533
NM_199478
PLP1

proteolipid protein 1

chrX_+_103031797 0.354 PLP1
proteolipid protein 1
chr1_-_171621750 0.354 NM_000261
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr10_+_11206928 0.350 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr13_+_108922205 0.344 TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr11_+_113659924 0.340 LOC390251
SH3-domain GRB2-like 1 pseudogene
chr7_-_2883649 0.336 NM_007353
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr5_+_155754172 0.333 SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr19_-_39368889 0.328 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr16_+_78056411 0.326 NM_005752
CLEC3A
C-type lectin domain family 3, member A
chr20_-_45061554 0.325 ELMO2
engulfment and cell motility 2
chr22_-_43343046 0.323 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr6_+_64286348 0.313 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr12_-_53730003 0.310 NM_001173467
SP7
Sp7 transcription factor
chr5_-_176326314 0.308 NM_002115
HK3
hexokinase 3 (white cell)
chr13_+_97928414 0.303 MBNL2
muscleblind-like 2 (Drosophila)
chr14_-_61190458 0.302 NM_017420
SIX4
SIX homeobox 4
chr2_-_154335181 0.302 NM_019845
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr13_+_49794471 0.299 NM_001507
MLNR
motilin receptor
chr16_+_21716283 0.299 NM_170664
OTOA
otoancorin
chrX_+_128913897 0.298 SASH3
SAM and SH3 domain containing 3
chr3_+_111718006 0.296 NM_001008273
TAGLN3
transgelin 3
chr16_+_89679715 0.293 NM_001128141
DPEP1
dipeptidase 1 (renal)
chr19_-_4302381 0.292 NM_001169126
NM_144615
TMIGD2

transmembrane and immunoglobulin domain containing 2

chrX_+_48242967 0.291 NM_001034832
NM_001040612
NM_005636
NM_175729
SSX4B

SSX4

synovial sarcoma, X breakpoint 4B

synovial sarcoma, X breakpoint 4

chr11_-_55703875 0.291 NM_006637
OR5I1
olfactory receptor, family 5, subfamily I, member 1
chr12_+_62954275 0.283 MON2
MON2 homolog (S. cerevisiae)
chr3_+_63884074 0.282 NM_001177387
ATXN7
ataxin 7
chr11_-_16497917 0.276 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr4_+_88571453 0.273 NM_001079911
NM_004407
DMP1

dentin matrix acidic phosphoprotein 1

chr18_+_55019720 0.268 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr3_+_35722428 0.266 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr18_+_43405544 0.266 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chr6_+_31514627 0.264 NM_001144962
NM_001144963
NFKBIL1

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

chr1_-_92951593 0.263 NM_001127216
GFI1
growth factor independent 1 transcription repressor
chr17_-_67311773 0.261 NM_018672
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr5_-_134782797 0.260 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr17_+_39388714 0.260 NM_031962
KRTAP9-9
KRTAP9-3
keratin associated protein 9-9
keratin associated protein 9-3
chr15_-_42749710 0.257 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr11_-_6817013 0.254 NM_003696
OR6A2
olfactory receptor, family 6, subfamily A, member 2
chr1_-_153013593 0.254 NM_006945
SPRR2D
small proline-rich protein 2D
chr4_+_15376174 0.252 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr1_+_215178884 0.249 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr17_-_60884010 0.248 NM_001100875
MARCH10
membrane-associated ring finger (C3HC4) 10
chr16_+_29831714 0.247 NM_005115
NM_017458
MVP

major vault protein

chr22_-_37823503 0.246 NM_052906
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr5_-_93077196 0.243 NM_153216
POU5F2
POU domain class 5, transcription factor 2
chr2_-_55277421 0.242 RTN4
reticulon 4
chr12_-_131002409 0.241 NM_015347
RIMBP2
RIMS binding protein 2
chr12_+_6309475 0.238 NM_001769
CD9
CD9 molecule
chrX_+_85517970 0.236 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr13_-_86373328 0.235 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr4_-_69536314 0.232 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr19_+_15838833 0.230 NM_013939
OR10H2
olfactory receptor, family 10, subfamily H, member 2
chr20_-_1638359 0.228 NM_001039508
NM_018556
NM_080816
SIRPG


signal-regulatory protein gamma


chrX_-_46618596 0.226 SLC9A7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr17_-_46035109 0.224 NM_024320
PRR15L
proline rich 15-like
chr10_-_931694 0.224 NM_015155
LARP4B
La ribonucleoprotein domain family, member 4B
chr2_-_55199894 0.222


chr2_-_163099877 0.221 NM_004460
FAP
fibroblast activation protein, alpha
chr1_-_183622447 0.217 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr19_+_51760963 0.217 NM_173635
C19orf75
chromosome 19 open reading frame 75
chr7_-_92855780 0.217 NM_001039372
HEPACAM2
HEPACAM family member 2
chr1_-_170038055 0.216 NM_001204517
KIFAP3
kinesin-associated protein 3
chr7_+_114066554 0.215 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr2_-_233877901 0.214 NGEF
neuronal guanine nucleotide exchange factor
chr16_+_29831755 0.213 MVP
major vault protein
chr2_+_233498206 0.211 NM_025202
EFHD1
EF-hand domain family, member D1
chr10_-_50122279 0.209 NM_001006939
LRRC18
leucine rich repeat containing 18
chr12_-_6745087 0.208 NM_020400
LPAR5
lysophosphatidic acid receptor 5
chr1_-_54199876 0.207 NM_147193
GLIS1
GLIS family zinc finger 1
chr15_+_44092618 0.206 NM_001199885
NM_016400
C15orf63

chromosome 15 open reading frame 63

chr7_+_31726630 0.205 NM_001145123
NM_006658
PPP1R17

protein phosphatase 1, regulatory subunit 17

chr6_-_127780534 0.204 NM_014702
KIAA0408
KIAA0408
chr18_+_77439843 0.198 CTDP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
chr2_+_169659099 0.198 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr16_+_2588021 0.195 PDPK1
3-phosphoinositide dependent protein kinase-1
chr7_+_113726364 0.193 FOXP2
forkhead box P2
chr19_+_37862055 0.190 NM_032453
ZNF527
zinc finger protein 527
chr8_+_120079423 0.190 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr2_-_225370687 0.185 CUL3
cullin 3
chr1_+_159409511 0.182 NM_012351
OR10J1
olfactory receptor, family 10, subfamily J, member 1
chr10_-_50342052 0.182 NM_001164484
FAM170B
family with sequence similarity 170, member B
chr15_+_92937104 0.182 NM_006011
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr11_-_116663106 0.181 NM_001166598
NM_052968
APOA5

apolipoprotein A-V

chr14_-_69260630 0.180 NM_001244698
NM_004926
ZFP36L1

zinc finger protein 36, C3H type-like 1

chr12_+_100750856 0.177 NM_001145288
NM_139319
SLC17A8

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

chr10_+_7745284 0.172 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr12_-_52867521 0.170 NM_173086
KRT6C
keratin 6C
chr13_+_108921976 0.168 NM_001145645
NM_006573
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr6_-_31514393 0.167 ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr15_+_52201590 0.166 TMOD3
tropomodulin 3 (ubiquitous)
chr6_+_11093991 0.165 C6orf228
chromosome 6 open reading frame 228

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
7.97 2.43e-02 GO:0003823 antigen binding